Lipids and Lipid Derivatives
Cayman Chemical C8 Ceramide-1-phosphate (d18:1/8:0) (ammonium salt), Purity: ≥90%, CAS: 474943-70-9, 1 mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
![Medchemexpress LLC [(2R)-2-hydroxy-3-tetracosanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 325171-59-3 | MFCD00674360 | 99.7% | 607.84 g/mol | C32H66NO7P | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222171.png-250.jpg)
Medchemexpress LLC [(2R)-2-hydroxy-3-tetracosanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 325171-59-3 | MFCD00674360 | 99.7% | 607.84 g/mol | C32H66NO7P | 5 MG
24:0 Lyso PC is a lysophospholipid supplied as a purified white to off-white solid for research use. It is used in studies of lipid metabolism and to formulate lipid nanoparticles for nucleic acid (mRNA) delivery, and is provided with documented chemical identity and stability data.
- Lysophospholipid useful for lipid nanoparticle formulation and mRNA delivery studies.
- High purity suitable for analytical and formulation research.
- White to off-white solid form, convenient for handling and storage.
- Stable under recommended storage conditions (powder at -20°C up to 3 years).
- Defined chemical identity and molecular weight for reproducible results.
TARGETMOL CHEMICALS INC C6 CERAMIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines. purity: 99%
Medchemexpress LLC N-Myristoyl-D-sphingosine | 34227-72-0 | MFCD01320386 | 99.9% | 509.85 g/mol | C32H63NO3 | 10MG
C14 ceramide (N-myristoyl-D-sphingosine) is a research-grade sphingolipid provided in ester form for laboratory use. It is intended for in vitro biochemical and cell biology studies of sphingolipid metabolism and signaling. The material is for research use only and is not for human or clinical applications.
Chemscene ChemScene | n-Octyl β-D-glucopyranoside | 25G | CS-0064659 | 0.98 | 29836-26-8| MFCD00063288 | 292.37
ChemScene | n-Octyl β-D-glucopyranoside | 25G | CS-0064659 | 0.98 | 29836-26-8| MFCD00063288 | 292.37
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3958841 SIGMA PACLITAXEL 300MG
Apexbio Technology LLC PACLITAXEL-D5-1MG
Paclitaxel-d5 (CAS No 1129540-33-5) is a deuterated analog of paclitaxel used in biomedical research primarily to study the pharmacokinetics and metabolism of the parent compound Originating from the bark of the Pacific yew tree paclitaxel acts by stabilizing microtubules and inhibiting their depolymerization thus blocking cell division and inducing apoptosis in cancer cells Its mechanism of action specifically affects the tubulin-microtubule pathway Paclitaxel-d5 exhibits activity in the nanomolar to low micromolar range in vitro making it a valuable tool in cell models and animal studies aimed at understanding cancer cell sensitivity or resistance to taxanes It is frequently used in drug screening assays to evaluate potential therapeutic efficacy or investigate drug interactions Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Nab-Paclitaxel 50mg | 50mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Selleck Chemical LLC Paclitaxel S1150-100mg
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | MFCD00135927 | 50 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It causes extremely prolonged channel opening and calcium influx, leading to cytotoxicity to TRPV1-positive pain fibers or cell bodies.
- Selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor
- Isolated from the Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- Causes prolonged channel opening and calcium influx
- Leads to cytotoxicity to TRPV1-positive pain fibers or cell bodies
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000388040-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
Cayman Chemical Phytol, Purity: ≥85% (mixture of isomers), CAS: 7541-49-3, 250 g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Apexbio Technology LLC Phytol 150-86-7 250g
Phytol is a naturally occurring diterpene alcohol derived from chlorophyll metabolism serving as an activator for retinoid X receptors (RXRs) RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways involving vitamins and hormones Phytol activates RXRs displaying Ki values ranging from 2 3 to 67 2 M In mammals phytol is metabolized to phytanic acid a reaction regulated by peroxisome proliferator-activated receptor (PPAR ) Additionally phytol interacts with GABA A receptors exhibiting sedative and anxiolytic properties and has been investigated as an antischistosomal candidate in animal models